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SERVICES
CUSTOM TMA
ROUTINE PATHOLOGY
IHC / IMMUNOFLUORESCENCE
ISH / FISH
CONTRACTED SERVICES
PRIMARY IHC ANTIBODIES
PATHOLOGY FIELD
Hermatopathology
DETECTION SYSTEMS
ANCILLARIES
CONTROL TMA
Publications
Ph.D.
Thesis:
Pan, L. Monoclonal antibodies to lactate dehydrogenase and creatine kinase isoenzymes and their application in tumor immunohistology. University College London Library Publication, 1988
Articles Published in Professional Journals:
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Pan, L., Diss, T.C., Cunningham, D., Isaacson, P.G. The bcl-2 gene in primary B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Am. J. Pathol. 135, 7-11, 1989
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Pan, L.X., Beverley, P.C., Bobrow, L.G., Swallow, D.M., Isaacson, P.G. Production of monoclonal antibodies to lactate dehydrogenase (LDH) isoenzymes for immunohistochemical study on fixed tissue section. Histochem. J. 21, 638-644, 1989
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Wotherspoon, A.C., Pan, L.X., Diss, T.C., Isaacson, P.G. A genotypic study of low grade B-cell lymphomas, including lymphomas of mucosa associated lymphoid tissue (MALT). J. Pathol. 162, 135-140, 1990
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Isaacson, P.G., Wotherspoon, A.C., Diss, T., Pan, L.X. Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am. J. Surg. Pathol. 15, 819-828, 1991
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Isaacson, P.G., Wotherspoon, A.C., Diss, T.C., Pan, L.X. Bcl-2 expression in lymphomas. Lancet. 337, 175-176, 1991
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Pan, L., Beverley, P.C., Isaacson, P.G. Lactate dehydrogenase (LDH) isoenzymes and proliferative activity of lymphoid cells--an immunocytochemical study. Clin. Exp. Immunol. 86, 240-245, 1991
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Pan, L.X., Xu, J.N., Isaacson, P.G. Cellular H- and M-type lactate dehydrogenase (LDH) isoenzymes and tumour diagnosis--an immunohistochemical assessment. J. Pathol. 163, 53-60, 1991
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Schmid, C., Pan, L., Diss, T., Isaacson, P.G. Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells. Am. J. Pathol. 139, 701-707, 1991
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Isaacson, P.G., Androulakis Papachristou, A., Diss, T.C., Pan, L., Wright, D.H. Follicular colonization in thyroid lymphoma. Am. J. Pathol. 141, 43-52, 1992
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Isaacson, P.G., Schmid, C., Pan, L., Wotherspoon, A.C., Wright, D.H. Epstein-Barr virus latent membrane protein expression by Hodgkin and Reed-Sternberg-like cells in acute infectious mononucleosis. J. Pathol. 167, 267-271, 1992
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Wotherspoon, A.C., Pan, L.X., Diss, T.C., Isaacson, P.G. Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer. Genet. Cytogenet. 58, 35-38, 1992
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Diss, T.C., Peng, H.Z., Wotherspoon, A.C., Pan, L., Speight, P.M., Isaacson, P.G. Brief report: a single neoplastic clone in sequential biopsy specimens from a patient with primary gastric-mucosa-associated lymphoid-tissue lymphoma and Sjogren's syndrome. N. Engl. J. Med. 329, 172-175, 1993
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Diss, T.C., Peng, H.Z., Wotherspoon, A.C., Isaacson, P.G., Pan, L. Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J. Pathol. 169, 291-295, 1993
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Pan, L., Happerfield, L.C., Bobrow, L.G., Isaacson, P.G. In situ detection of human Ig light-chain mRNA on formalin-fixed and paraffin-embedded tissue sections using digoxigenin-labelled RNA probes. Histochem. J. 25, 57-63, 1993
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Pan, L., Diss, T.C., Peng, H.Z., Lu, Q., Wotherspoon, A.C., Thomas, J.A., Isaacson, P.G. Epstein-Barr virus (EBV) in enteropathy-associated T-cell lymphoma (EATL). J. Pathol. 170, 137-143, 1993
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Wotherspoon, A.C., Doglioni, C., Diss, T.C., Pan, L., Moschini, A., de Boni, M., Isaacson, P.G. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 342, 575-577, 1993
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Wotherspoon, A.C., Diss, T.C., Pan, L.X., Schmid, C., Kerr-Muir, M.G., Lea, S.H., Issacson, P.G. Primary low-grade B-cell lymphoma of the conjunctiva: a mucosa-associated lymphoid tissue type lymphoma. Histopathology. 23, 417-424, 1993
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Diss, T.C., Pan, L.X., Peng, H.Z., Wotherspoon, A.C., Isaacson, P.G. Sources of DNA for detecting B cell monoclonality using PCR. J. Clin. Pathol. 47, 493-496, 1994
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Pan, L.X., Diss, T.C., Peng, H.Z., Isaacson, P.G. Clonality analysis of defined B-cell populations in archival tissue sections using microdissection and polymerase chain reaction. Histopathology. 24, 323-327, 1994
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Peng, H.Z., Isaacson, P.G., Diss, T.C., Pan, L.X. Multiple PCR analyses on trace amounts of DNA extracted from fresh and paraffin wax embedded tissues after random hexamer primer PCR amplification. J. Clin. Pathol. 47, 605-608, 1994
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Diss, T.C., Watts, M., Pan, L., Linch, D., Isaacson, P.G. The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas. J. Clin. Pathol. 48, 1045-1050, 1995
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Diss, T.C., Wotherspoon, A.C., Speight, P.M., Pan, L.X., Isaacson, P.G. B cell monoclonality, Epstein Barr virus and t(14;18) in myoepithelial sialadenitis and low grade B cell MALT lymphoma of the parotid gland. Am. J. Surg. Pathol. 19, 531-536, 1995
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Du, M.Q., Peng, H.Z., Singh, N., Isaacson, P.G., Pan, L.X. The accumulation of p53 abnormality is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood. 86(12), 4587-4593, 1995
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Pan, L.X., Ramani, P., Diss, T.C., Liang, J.N., Isaacson, P.G. Epstein-Barr virus associated lymphoproliferative disorder with fatal involvement of the gastrointestinal tract in an infant. J. Clin. Pathol. 48, 390-392, 1995
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Peng, H.Z., Du, M.Q., Ji, J.X., Isaacson, P.G., Pan, L.X. High-resolution SSCP analysis using acrylamide-agarose composite gel and a background free silver staining method. Biotechniques. 19(3), 410-413, 1995
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Pan, L.X., Diss, T.C., Isaacson, P.G. Invited review: The polymerase chain reaction in histopathology. Histopathology. 26, 201-217, 1995
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Ashton-Key, M., Singh, N., Pan, L.X., Isaacson, P.G., Smith, M.E.F. MHC antigen expression in enteropathy associated T cell lymphoma. J. Clin. Pathol. 49, 545-548, 1996
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Du, M.Q., Singh, N., Husseuin, A., Isaacson, P.G., Pan, L.X. Positive correlation between apoptotic and proliferative indices in gastrointestinal lymphomas of mucosa-associated lymphoid tissue (MALT). J. Pathol. 178, 379-384, 1996
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Du, M.Q., Diss, T.C., Xu, C.F., Peng, H.Z., Isaacson, P.G., Pan, L.X. Ongoing mutation in MALT lymphoma immunoglobulin VH gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia. 10, 1190-1197, 1996
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Du, M.Q., Xu, C.F., Diss, T.C., Peng, H.Z., Wotherspoon, A.C., Isaacson, P.G., Pan, L.X. Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma. Blood. 88, 4445-4451, 1996
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Nicholson, A.G., Wotherspoon, A.C., Diss, T.C., Singh, N., Butcher, D.N., Pan, L.X., Isaacson, P.G., Corrin, B. Lymphomatoid granulomatosis: evidence that some cases represent Epstein-Barr virus-associated B-cell lymphoma. Histopathology. 29, 317-324, 1996
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Pan, L.X., Diss, T.C., Peng, H.Z., Isaacson, P.G. Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder? Blood. 87, 2428-2434, 1996
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Peng, H.Z., Chen, G., Du, M.Q., Singh, N., Isaacson, P.G., Pan, L.X. Replication error (RER) and p53 gene mutation in lymphomas of mucosa-associated lymphoid tissue (MALT). Am. J. Pathol. 148, 643-648, 1996
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Savio, A., Franzin, G., Wotherspoon, A.C., Zamboni, G., Negrini, R., Buffoli, F., Diss, T.C., Pan, L., Isaacson, P.G. Diagnosis and posttreatment follow-up of helicobacter pylori-positive gastric lymphoma of mucosa-associated lymphoid-tissue - histology, polymerase chain-reaction, or both. Blood. 87, 1255-1260, 1996
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Wotherspoon, A.C., Diss, T.C., Pan, L., Singh, N., Whelan, J., Isaacson, P.G. Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid-tissue in immunocompromised patients. Histopathology. 28, 129-134, 1996
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Pan, L.X., Diss, T.C., Peng, H.Z., Isaacson, P.G. Immersion-histo polymerase chain reaction - a practical tool for visualization of single-copy genes in tissue sections. Am. J. Pathol. 150, 1245-1252, 1997
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Peng, H.Z., Du, M.Q., Diss, T.C., Isaacson, P.G., Pan, L.X. Clonality analysis in tumours of women by PCR amplification of X-linked genes. J. Pathol. 181, 223-227, 1997
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Du, M.Q., Diss, T.C., Xu, C.F., Wotherspoon, A.C., Isaacson, P.G., Pan, L.X. Ongoing immunoglobulin gene mutations in mantle cell lymphomas. Br. J. Haematol. 96, 124-131, 1997
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Peng, H., Du, M., Diss, T.C., Isaacson, P.G., Pan, L. Genetic evidence for a clonal link between low- and high-grade components in gastric MALT B cell lymphoma. Histopathology. 30, 425-429, 1997
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Du, M.Q., Peng, H.Z., Dogan, A., Diss, T.C., Liu, H., Pan, L.X., Mosley, R.P., Briskin, M.J., Chan, J.K., Isaacson, P.G. Preferential dissemination of B-cell gastric mucosa-associated lymphoid tissue (MALT) lymphoma to the splenic marginal zone. Blood 90, 4071-4077, 1997
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Ashton-Key, M, Diss, T.C., Pan, L, Du, M.Q., Isaacson, P.G. Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy associated T cell lymphoma. Am. J. Pathol. 151, 493-498 1997
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Peng, H, Diss, T, Isaacson, P.G., Pan, L. C-myc gene abnormalities in mucosa associated lymphoid tissue (MALT) lymphomas. J. Pathol. 181, 381-386, 1997
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Pan, L.X., Peng, H.Z. High-resolution silver staining-based PCR-single strand conformation polymorphism (SSCP) analysis. In: Schaefer,B.C. ed., Gene cloning and analysis - current innovations, Norfolk, England, Horizon scientific press, 1997, 191-202
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Diss, T.C., Pan, L. Polymerase chain reaction in the assessment of lymphomas. In: Tooze,J., Franks,L.M. eds., Cancer surveys, Cold Spring Harbor Laboratory Press, 1997, 21-43
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Deng Z, Pan L, Ma Y: [Sequence alterations in p53 gene of hepatocellular carcinoma from high aflatoxin risk area in Guangxi]. [Chinese]. Chung-Hua Chung Liu Tsa Chih [Chinese Journal of Oncology] 19,18-21 1997
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Dogan A, Du MQ, Aiello A, Diss TC, Ye HT, Pan LX, Isaacson PG. Follicular lymphomas contain a clonally linked but phenotypically distinct neoplastic B-cell population in the interfollicular zone. Blood 91, 4708-4714, 1998
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Peng, H.Z., Isaacson, P.G., Pan, LX. Infrequent mutations of the Bax gene in B-cell lymphomas. J. Pathol. 186, 378-382 1998
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Peng, H, Ranaldi, R., Diss, T, Isaacson, P.G., Bearzi, I, Pan, L. High frequency of CagA+ helicobacter pylori infection in high-grade gastric MALT B-cell lymphomas. J. Pathol. 185, 409-412, 1998
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Peng, H.Z., Du, M.Q., Koulis, A., Aiello, A., Dogan, A., Pan, L.X., Isaacson, P.G. Non-Ig gene hypermutation in germinal centre B cells. Blood. 93 2167-2172, 1999
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Willis, T.G., Dalal M, Du, M.Q., Peng, H, Perry, A.R, Abdul-Rauf, M, Price, H., Karran, L., Majekodunmi, O, Wlodarska, I, Pan, L.X., Crook, T, Hamoudi, R., Isaacson, P.G., Dyer, M.J.S. Bcl 10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 96, 35-45, 1999
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Bai, X.Z., Masters, J.R., O’Donoghue, N., Kirby, R., Pan, L.X., Young, M., Stafford, M., Parkinson, M.C. Prognostic markers in clinically localized prostate cancer. Int. J. Oncol. 14, 785-791, 1999
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Tsang, P, Pan, L, Cesarman, E, Tepler, J, Knowles, D.M. A distinctive composite lymphoma comprised of a clonally related mantle cell lymphoma and follicle center cell lymphoma. Hum Pathol. 30, 988-992, 1999
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Aiello, A., Du, M.Q., Diss, T.C., Peng, H.Z., Pezzella, F., Papini, D., Giardini, R., Pilotti, S., Pan, L.X., Isaacson, P.G. Simultaneous phenotypically distinct but clonaly identical mucosa-associated lymphoid tissue and follicular lymphoma in a patient with Sjogren’s syndrome. Blood. 94, 2247-2251, 1999
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Diss, T.C., Pan, L.X., Du, M.Q., Parkinson, M.C., Peng, H.Z., Isaacson, P.G., Kerr, J. Parvovirus B19 is associated with benign testicular tissue as well as testicular germ cell tumours. Molecular Pathology, 52, 349-352, 1999
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Barnouin, K., Fredersdorf, S., Eddaoudi, A., Mittnacht, S., Pan, L.X., Du, M.Q., Lu, X. Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt’s lymphoma cells. Oncogene, 18, 6388-6397, 1999
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Peng, H.Z., Lakhani, S.R., Lee, C.Y., Zheng, Q., Chaggar, R.K., Wright, N., Isaacson, P.G., Pan, L.X. X-linked gene transcription-based clonality analysis of defined cell populations on archival paraffin-embedded tissue sections using microdissection and RT-PCR. J. Pathol. 191, 313-317, 2000
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Pan, L.X., Cesarman, E., Knowles, D.M. Antigen receptor genes: structure, function, and techniques for analysis of their rearrangements. In: Knowles, D.M. eds., Neoplastic Hematopathology, Williams & Wilkins, 2000
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Pan, L., Peng, H. Polymerase chain reaction clonality assays based on X-linked genes. In: Killeen, A. eds., Molecular Pathology Protocols, Human Press, Chapter 8, 73-79, 2000
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Du, M.Q., Diss, T.C., Dogan, A., Ye H.T., Aiello A., Wotherspoon A.C., Pan, L.X., Isaacson, P.G. Clone-specific PCR reveals wide dissemination of gastric MALT lymphoma to the gastric mucosa. J. Pathol. 192, 488-493, 2000
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Kuhel, W.I., Gonzales, D., Hoda, S.A., Pan, L., Chiu, A., Giri, D., DeLellis, R.A. Synchronous water-clear cell double parathyroid adenoma – a hitheto uncharacterized entity? Arch. Pathol. Lab. Med. 125, 256-259, 2001
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Pan, L., Milligan, L., Michaeli, J., Cesarman, E., Knowles, D.M. Polymerase chain reaction (PCR) detection of kaposi’s sarcoma-associated herpesvirus (KSHV) – variations of methods, primer sets and target sequences. J Mole Diag. 3, 32-38, 2001
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Chiu, A., Pan, L.X., Li, Z.D., Ely, S., Chadburn, A.,Knowles, D.M. DNA polymerase Mu gene expression in B-cell non-Hodgkin’s lymphomas: an analysis utilizing in-situ hybridization. Am. J. Pathol. 161, 1349-55, 2002
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Li, Z.D., Pan, L, Cesarman, E, Knowles, D.M. Alterations of mRNA splicing in primary effusion lymphomas. Leuk Lymphoma. 44, 833-40, 2003
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Hamoudi, R., Diss, T.C., Oksenhendler, E., Pan, L., Carbone, A., Ascoli, V., Langerak, A.W., Boshoff, C., Isaacson, P., Du, M.Q. Distinct cellular origins of primary effusion lymphoma with and without EBV infection. Leukemia Research. 28, 333-38, 2004
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Alobeid, A., Pan, L.X., Frizzera, G. Eosinophil-rich lymphoproliferative disorder of the oral mucosa. a form of “traumatic eosinophilic granuloma”. Am J Clin Pathol. 121, 43-50, 2004